Who Are The Top Players in Deep Tech VC (2025)

Who Are The Top Players in Deep Tech VC

As you know, the deep tech venture capital landscape has exploded this year, but who are the top players in deep tech VC?

The sector is attracting unprecedented investment as transformative technologies reshape entire industries.

From artificial intelligence and quantum computing to biotechnology and advanced robotics, deep tech represents the cutting edge of innovation, and the investors funding these breakthroughs are becoming household names in the startup ecosystem.

Understanding who the top players are can help founders identify the right partners for their groundbreaking ventures.

Who Are The Top Players in Deep Tech VC

Deep tech is no longer a niche category.

In 2025 through September, deep tech companies raised $139 billion in equity funding across 1,970 rounds, representing a remarkable 128% increase compared to the same period in 2024.

The deep tech market is projected to reach $714.6 billion by 2031, growing at an impressive compound annual growth rate of 48.2%.

What makes deep tech investing unique is the long development cycles, significant R&D requirements, and specialized expertise needed to evaluate opportunities.

The top VC firms in this space understand these dynamics and bring not just funding, but strategic value to their portfolio companies.

The Elite Deep Tech VC Firms

Firm Focus Areas Notable Investments Investment Stage
Lux Capital AI, biotech, robotics, space tech Anduril, Zoox, Heliogen Seed to Series A
DCVC AI, machine learning, computational science Planet Labs, Recursion, Benchling Series A+
SOSV Biotech, food tech, robotics, hardware IndieBio & HAX portfolio companies Pre-seed to Seed
Andreessen Horowitz AI, robotics, healthcare, life sciences Oculus VR, Cloudera, OpenAI Seed to Growth
Khosla Ventures Energy, space, materials, agtech, biotech Climate tech and biotech leaders Seed to Series B
Two Sigma Ventures Computer vision, ML, AI, data science 3DR, Anomalo, Enigma Seed to Series A+
Boost VC Aerospace, VR/AR, crypto, bio, AI/ML Coinbase, Starfish Space, K2 Space Pre-seed

1. Lux Capital

Top Players in Deep Tech VC: Lux Capital

Lux Capital has built its reputation on making risky bets where technology intersects with world-changing ideas, focusing heavily on AI, robotics, biotech, and space tech.

With over 20 years of experience and $5 billion in assets under management, Lux doesn’t just fund companies; they champion technologies that others might consider too ambitious or too far from commercialization.

2. DCVC

Top Players in Deep Tech VC: DCVC

DCVC specializes in funding data-driven enterprises tackling hard science innovation, with particular expertise in artificial intelligence, machine learning, and computational science.

Their portfolio reads like a who’s who of companies using advanced technology to solve fundamental problems in industries ranging from agriculture to pharmaceuticals.

3. SOSV

Top Players in Deep Tech VC: SOSV

SOSV provides not just funding but a strong mentorship ecosystem for hard tech founders through programs like IndieBio and HAX, focusing on biotech, food tech, robotics, and hardware.

Managing over $1.5 billion in assets with a focus on deep tech and planetary health investments, SOSV has become synonymous with early-stage deep tech acceleration.

4. The Generalist Powerhouses

Top Players in Deep Tech VC: Sequoia

While specialized deep tech firms have carved out impressive niches, generalist giants like Andreessen Horowitz (a16z) and Sequoia Capital continue to deploy significant capital into deep tech opportunities.

A16z has been particularly active in deep tech, launching a $200 million fund exclusively for AI investments in 2016 and a $450 million fund for healthcare and life sciences in 2018.

Their portfolio includes groundbreaking companies like Oculus VR and OpenAI.

Investment Trends Shaping Deep Tech

Sector 2025 Investment Highlights Key Drivers
AI & Machine Learning 51% of all VC funding; $89.4B raised by AI startups Generative AI, enterprise applications, automation
Quantum Computing $1B+ mega-rounds (PsiQuantum, Quantinuum) Breakthrough computational capabilities, defense applications
Space Tech $6B in 2024; continued momentum in 2025 Satellite manufacturing, space-based solar power, and microgravity
Biotech & Life Sciences Record Series A rounds; gene therapy advancement Precision medicine, RNA therapeutics, protein sequencing
Robotics & Hardware Growing focus on industrial automation & defense Labor shortages, supply chain resilience, AI integration

Sector-Specific Deep Tech Investors

Beyond broad-based deep tech firms, sector-specific investors have emerged as powerful players in their respective domains.

Konvoy

Konvoy

Konvoy, a leading example of sector-focused deep tech investing, exclusively targets the video gaming ecosystem where innovations like AI, advanced graphics rendering, and VR/AR converge.

Beyond broad-based deep tech firms, these specialized investors have emerged as powerful players in their respective domains.

Gaming technology increasingly overlaps with broader deep tech applications, from real-time 3D simulation to immersive experiences.

Sector-focused investors like Konvoy bring both capital and invaluable industry connections that generalist firms cannot match.

Conclusion

The top players in deep tech VC are characterized by unprecedented capital deployment, specialized expertise, and recognition that transformative innovation requires patient, strategic investment.
Firms like Lux Capital, DCVC, SOSV, and the deep tech arms of generalist giants are not just funding companies.
They’re enabling the breakthrough technologies that will address climate change, revolutionize healthcare, and push the boundaries of human capability.
For founders working on hard science problems, understanding who these players are and what they bring beyond capital is essential to securing the right partnerships for long-term success.

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