Top 20 Venture Capital Firms in Boston (2025)

If you are looking for the best venture capital firms in Boston, you probably already know this.

Boston is known for innovation, entrepreneurship, and technology.

By 2025, the startup landscape in Boston is still shifting.

Plenty of firms are stepping up to help startups grow across different sectors.

These companies do more than just give money to startups; they actively support them to achieve success.

In this article, we will look at the top 20 venture capital firms in Boston that are influencing the future of innovation.

Best Venture Capital Firms in Boston

Boston, along with Denver, Chicago, and New York, has a lively environment for startups.

If you are a founder looking to raise money, it’s important to know the top venture capital firms in Boston.

1. Summit Partners

Summit Partners is a growth-equity firm that started in 1984 with a collaborative approach to investing.

Summit Partners is one of the top venture capital firms in Boston and they have raised over $32 billion for more than 550 companies.

Their main areas of investment include Technology, Healthcare & Life Sciences, and Growth Products & Services.

2. General Catalyst Partners

General Catalyst is one of leading venture capital firms in Boston that invests in different funding stages, including Seed, Series A, Series B, and Growth rounds.

They invest across various sectors, focusing mainly on consumer products, enterprise solutions, fintech and crypto, and health assurance.

Some of their well-known investments are in companies like Stripe and HubSpot.

3. Volition Capital

Volition Capital is a growth equity firm established in 2010.

As one of the leading venture capital firms in Boston, Volition Capital has a portfolio of 26 companies in the United States and Europe.

The firm focuses on software, internet, information services, and tech-enabled services companies that practice good operations and aspire to achieve great things.

4. Battery Ventures

Battery Ventures invests in several areas, including application software, infrastructure software, consumer products, and industrial technology, as stated on their website.

Since 1983, they have been one of the top venture capital firms in Boston and have funded over 450 companies.

Battery Ventures invests in companies at all stages and across the globe.

5. 424 Capital

424 Capital is a growth capital partner based in Boston that completes 1 to 5 add-on acquisitions during their investment period.

As one of the top venture capital firms in Boston, they work with you to create a strategy for your company’s success.

424 Capital invests in profitable, tech-driven service companies with high potential, as well as in healthcare and green energy.

6. Polaris Partners

Polaris Partners is one of the top venture capital firms in Boston.

They have been investing in healthcare businesses for over 20 years.

Polaris has raised 10 funds to support companies in healthcare and technology.

Some of their well-known investments include Syros, SimplyInsured, and Amunix.

7. Anzu Partners

Anzu Partners is one of the leading venture capital firms in Boston that invests in innovative industrial technologies.

Anzu manages about $1 billion in strategic assets across three venture funds.

They focus on partnering with entrepreneurs to develop and bring technological innovations to market.

Anzu provides capital and expertise in business development, market positioning, global connections, and operations.

8. .406 Ventures

.406 Ventures is one of the top venture capital firms in Boston.

They focus on early-stage companies in cybersecurity, digital health, and data and cloud services.

.406 Ventures typically invests between $2 million and $5 million.

Some of their well-known investments include Compass, Nomad Health, and Randori.

9. NAV.VC

NAV.VC, also called New Atlantic Ventures, is a venture capital firm that invests in early-stage companies across the U.S.

They focus on mobile technology, e-commerce, cybersecurity, education, advertising technology, and healthcare.

NAV.VC is recognized as one of the top venture capital firms in Boston.

They have helped start over 100 companies, including Massive, Moda Operandi, Qliance, Solve Media, and Stitcher Radio.

10. OpenView

OpenView Partners helps companies with growth during their expansion stage.

As one of the leading venture capital firms in Boston, they focus on companies in the future of work and expansion stage.

It’s not surprising that OpenView’s portfolio includes companies like Calendly and Lessonly.

11. MassVentures

MassVentures is a venture capital firm that invests in early-stage startups with high growth potential in Massachusetts.

The firm focuses on areas where funding is often hard to find, especially in seed funding, post-seed funding, and between Series A and B rounds.

Along with funding, MassVentures provides strategic advice, operational support, and connects companies to a network of experts.

12. 1414 Ventures

1414 Ventures invests in companies that create innovative digital identity solutions.

They are a well-established venture capital firm based in Boston, focusing on pre-seed and seed-stage companies.

1414 Ventures specifically looks for businesses that develop solutions to address cybersecurity threats related to digital identity.

13. Matrix Partners

Since it started in 1977, Matrix Partners has worked with many founders.

They have helped build numerous successful businesses, with over 50 going public and more than 75 being sold profitably.

Matrix Partners operates across the United States, India, and China in various sectors and at different stages.

14. Mendoza Ventures

You have probably used Canva at least once.

Mendoza Ventures was one of the first investment firms to support it.

They focus on companies in Fintech, AI, and Cybersecurity, especially in early and growth stages.

As a top venture capital firm in Boston, Mendoza is managed by Adrian and Senofer Mendoza, a husband and wife team and seasoned entrepreneurs who have experience in the Boston start-up scene.

15. Flybridge Capital Partners

Flybridge Capital Partners is an investment firm with over 20 years of experience.

They support founders and operators who are making a difference in their industries.

They are one of the top early-stage venture capital firms in Boston.

With more than $600 million in assets across four funds, they have invested in over 80 companies.

16. HLM Venture Partners

HLM Venture Partners stands out as one of the premier venture capital firms in Boston, with a strong focus on healthcare services and companies.

Unlike many others in this field, HLM specializes in providing early to mid-stage funding and has made investments in over 75 companies.

Among their notable portfolio are well-regarded enterprises such as Able To and Blue Rabbit.

17. Highland Capital Partners

Highland Capital Partners has one main goal: to help talented people build great companies.

Since 1988, the firm has invested in over 200 companies at seed, early, and growth stages.

Impressively, 90 of these companies have gone public or been acquired, including 40 Unicorns in their portfolio.

As one of the top venture capital firms in Boston, they work closely with entrepreneurs.

They provide strategic advice, hands-on leadership, and deep industry knowledge.

18. Venrock

Venrock has established itself as a key player in the venture capital arena.

Their investment portfolio includes notable names such as Apple, Nest, and Zoominfo.

Pretty impressive, huh?

Throughout their history, they have backed 700 companies and successfully raised 10 funds.

Venrock focuses on investing in technology and healthcare firms at all stages of development.

They continue to be regarded as one of the leading venture capital firms in Boston.

19. Boston Seed Capital

Boston Seed Capital is a well-known venture capital firm that invests in early-stage technology companies.

They focus on pre-seed and seed-stage companies and usually invest between $250,000 and $2.5 million in these seed rounds.

Boston Seed Capital’s interests include software, digital media, e-commerce, and internet services.

Founders who work with Boston Seed Capital gain access to the firm’s wide network, expertise, and a strong commitment to helping businesses succeed.

20. Underscore VC

Underscore VC is a venture capital firm that started in 2015.

In just 10 years, it has become one of the top venture capital firms in Boston.

The firm focuses on supporting bold entrepreneurs in the early stages, especially in the B2B software sector.

Underscore VC invests in companies at various stages: pre-seed, seed, Series A, Series B, and Series C. They usually invest around $4 million but can invest up to $10 million.