San Francisco has long been synonymous with startups and venture capital.
The city has many companies ready to invest in the next big idea, like a new Facebook.
As the tech hub of the United States, San Francisco has seen countless startups emerge, many of which have thrived thanks to the support and insights of prominent venture capital firms.
In this post, we’ll walk you through the top venture capital firms in San Francisco for 2025.
Best Venture Capital Firms in San Francisco
Next to New York, LA, and Denver, the venture capital scene in San Francisco is changing in 2025.
Let’s look at the top 10 venture capital firms in San Francisco that are influencing the future of entrepreneurship.
1. Andreessen Horowitz (a16z)
Andreessen Horowitz, or a16z, is a well-known venture capital firm in San Francisco’s tech scene.
It was founded by Marc Andreessen and Ben Horowitz.
The firm is recognized for its deep knowledge of technology and its ability to find and support promising startups.
a16z invests in a variety of companies, from early-stage to more mature technology businesses.
The firm focuses on areas like AI, biotech and healthcare, consumer products, cryptocurrency, enterprise solutions, fintech, gaming, infrastructure, and projects that encourage American growth.
As one of the best venture capital firms in San Francisco, it manages $45 billion in committed capital across different funds.
2. Accel
Accel is one of the best venture capital firms in San Francisco. With over 40 years of experience, it is known for boosting iconic companies like Atlassian, Bumble, and Spotify through various growth phases.
Accel’s investment philosophy focuses on backing outstanding teams to build global businesses, offering capital and strategic guidance from seed stage to IPO.
The firm specializes in diverse industries, including Cloud Computing, Consumer Internet, Enterprise Software, Financial Technology, Healthcare, and Cybersecurity.
3. Greycroft Partners
Greycroft Partners is widely regarded as one of the leading venture capital firms in San Francisco.
With over $1 billion in assets under management, Greycroft boasts a diverse portfolio that includes more than 150 investments across various sectors.
Some of its notable early-stage investments feature well-known companies like Acorns, Venmo, and TheRealReal, and span fields such as fintech, e-commerce, media, and healthcare.
The firm particularly focuses on supporting software, sustainability, and consumer brands ventures.
4. Sequoia Capital
Sequoia Capital is one of the top venture capital firms in San Francisco at the moment.
They are known for their skill in finding groundbreaking technologies and talented entrepreneurs.
Sequoia has invested in some of the most successful tech companies today, including Figma, Zoom, and Dropbox.
With their deep industry knowledge, wide network, and hands-on approach, Sequoia is a highly sought-after partner for entrepreneurs in the Bay Area.
5. Kleiner Perkins
Kleiner Perkins is one of the most famous venture capital firms in San Francisco and was was founded over fifty years ago.
They have supported hundreds of companies that became leaders in their industries.
Kleiner Perkins has invested $10 billion through twenty venture funds and four growth funds.
Some of their most famous investments include Amazon, Genentech, and Google.
The firm has a long history of working with smart and innovative founders to bring new ideas to the market.
6. First Round Capital
First Round Capital is one of the top venture capital firms in San Francisco.
They specialize in investing in tech-driven startups from various industries, including enterprise software, fintech, consumer technologies, and healthcare.
First Round Capital’s focus on being the first investor is unique.
They provide important seed funding that helps startups launch and grow until they can get Series A funding.
These early investments usually range from $1 million to $5 million, with an average of about $3 million.
7. Benchmark
Benchmark is a venture capital firm based in San Francisco, renowned for its selective investment strategy and its knack for discovering and supporting promising startups.
Benchmark has established itself as one of the premier venture capital firms in San Francisco, focusing primarily on early-stage companies.
Some well-known companies in its portfolio include Uber and Instagram.
The firm’s biggest success came from a $6.7 million investment in eBay in 1997, giving them a 22.1% ownership stake.
8. Lightspeed Venture Partners
Lightspeed Venture Partners is a global venture capital firm that invests in companies at different stages.
They focus on innovative ideas in various areas such as enterprise, consumer products, health, and fintech.
For over 20 years, Lightspeed has been recognized as one of the top venture capital firms in San Francisco.
They have helped more than 500 companies grow and succeed worldwide.
Some well-known companies in their portfolio include Affirm, Cato Networks, Epic Games, Faire, and Forty Seven.
9. Index Ventures
Index Ventures is a venture capital firm based in San Francisco focusing on technology and innovation.
The firm has invested in companies like Notion, Figna, and Roblox, showing its skill in finding and supporting disruptive startups.
With its global reach and commitment to supporting entrepreneurs, Index Ventures is considered one of the top venture capital firms in San Francisco.
10. Founders Fund
Founders Fund is part of the long list of premier venture capital firms in San Francisco.
Founders Fund invests in new and innovative ideas in various stages, sectors, and locations. They focus on smart people working on tough problems.
Their portfolio includes well-known companies like PayPal and Airbnb.
Founders Fund is open to supporting companies at different points in their development, from early concepts to growth and expansion.
In Summary
The top venture capital firms in San Francisco have a strong portfolio of well-known companies that have changed our lives and will continue to shape our future.
They are also dedicated to making a positive impact in the world.
These firms support founders who have innovative ideas for the future.
We recommend checking out our Ultimate Guide to Types of Venture Capital Funding to learn more about venture capital and how to start a career in this field.
